Intraoralelectrostimulator for xerostomia relief : along-term, multicenter, open-label, uncontrolled, clinical trial

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Intraoralelectrostimulator for xerostomia relief : along-term, multicenter, open-label, uncontrolled, clinical trial

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dc.contributor.author Alajbeg, Ivan
dc.contributor.author Falcão, Denise P
dc.contributor.author Tran, Simon D
dc.contributor.author Martín-Granizo, Rafael A
dc.contributor.author Lafaurie, Gloria I
dc.contributor.author Bautista Mendoza, Gloria R
dc.contributor.author Pejda, Slavica
dc.contributor.author Vuletić, Lea
dc.contributor.author Mantilla, Rubén
dc.contributor.author Leal, Soraya C
dc.contributor.author Barreto Bezerra, Ana C
dc.contributor.author Ménard, Henri A
dc.contributor.author Kimoto, Suguru
dc.contributor.author Pan, Shaoxia
dc.contributor.author Maniegas Lozano, María L
dc.contributor.author Krushinski, Cheryl A
dc.contributor.author Melilli, Dario
dc.contributor.author Campisi, Giuseppina
dc.contributor.author Paderni, Carlo
dc.contributor.author Matranga, Domenica
dc.contributor.author Yepes, Juan F
dc.contributor.author Lindh, Liselott
dc.contributor.author Koray, Meltem
dc.contributor.author Mumcu, Gonca
dc.contributor.author Elad, Sharon
dc.contributor.author Zeevi, Itai
dc.contributor.author Aldape, Beatriz C
dc.contributor.author López Sánchez, Rodrigo M
dc.contributor.author Lassauzay, Clarie L
dc.contributor.author Fromentin, Olivier
dc.contributor.author Beiski, Ben Z
dc.contributor.author Strietzel, Franz P
dc.contributor.author Konttinen, Yrjö T
dc.contributor.author Wolff, Andy
dc.contributor.author Zunt, Susan L
dc.date.accessioned 2012-10-24T09:59:06Z
dc.date.available 2012-10-24T09:59:06Z
dc.date.issued 2012 en_US
dc.identifier.citation 773-781 en_US
dc.identifier.issn 2212-4403 en_US
dc.identifier.uri http://hdl.handle.net/2043/14262
dc.description.abstract OBJECTIVE: A previous sham-controlled multinational study demonstrated the short-term efficacy and safety for xerostomia treatment of an intraoral device that delivers electrostimulation to the lingual nerve. The objective of this study was to test the hypothesis that those beneficial effects would be sustained over an 11-month period. STUDY DESIGN: The device was tested on a mixed sample of 94 patients with xerostomia in an open-label, uncontrolled, prospective multicenter trial. Statutory outcome assessments were done at 5th, 8th, and 11th months and analyzed by multiple comparisons. RESULTS: Improvements achieved at month 5 from baseline were sustained throughout the follow-up period for the primary outcome, xerostomia severity, and the secondary outcomes resting whole salivary flow rate, xerostomia frequency, oral discomfort, and difficulties in speech, swallowing, and sleeping. No significant side effects were detected. CONCLUSIONS: The beneficial effects of a removable intraoral electrostimulating device were sustained for an 11-month period. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.subject.classification Medicine en_US
dc.title Intraoralelectrostimulator for xerostomia relief : along-term, multicenter, open-label, uncontrolled, clinical trial en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology
dc.identifier.doi http://dx.doi.org/10.1016/j.oooo.2012.01.012 en_US
dc.subject.srsc Research Subject Categories::ODONTOLOGY en_US
dc.relation.ispartofpublication Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology;6
dc.relation.ispartofpublicationvolume 113 en_US
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