Influence of pH on the build-up of poly-L-lysine/heparin multilayers

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Influence of pH on the build-up of poly-L-lysine/heparin multilayers

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Publication Article, peer reviewed scientific
Title Influence of pH on the build-up of poly-L-lysine/heparin multilayers
Author(s) Barrantes, Alejandro ; Santos, Olga ; Sotres, Javier ; Arnebrant, Thomas
Date 2012
English abstract
The effect of pH on the build-up-of polyelectrolyte multilayers, PEMs, composed by poly-L-lysine and heparin onto two different substrates, silica and gold, has been studied by means of ellispmetry and quartz crystal microbalance with dissipation, QCM-D. Ellipsometry results indicate that the dry mass grows exponentially with the number of layers, and that this amount is larger as the pH values are raised. From QCM-D data the viscoelastic properties of the multilayered structure have been obtained. These data reflect that PEMs become more viscoelastic as the pH values are increased for silica substrates, while for gold the highest viscoelastic behavior is obtained at neutral pH and the elastic behavior becomes dominant as the pH is further increased or decreased. By combining these two surface techniques it has been also possible to determine the solvent content in the multilayers and reach a deeper understanding of the internal structure.
DOI http://dx.doi.org/10.1016/j.jcis.2012.08.008 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Journal of Colloid and Interface Science;1
Volume 388
ISSN 0021-9797
Pages 191-200
Language eng (iso)
Subject(s) Polyelectrolyte multilayers
Ellipsometry
QCM-D
Viscoelastic properties
Poly-L-lysine
Heparin
Viscoelasticity
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/14293 (link to this page)

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