Influence of pH on the build-up of poly-L-lysine/heparin multilayers

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Influence of pH on the build-up of poly-L-lysine/heparin multilayers

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dc.contributor.author Barrantes, Alejandro
dc.contributor.author Santos, Olga
dc.contributor.author Sotres, Javier
dc.contributor.author Arnebrant, Thomas
dc.date.accessioned 2012-11-02T08:26:41Z
dc.date.issued 2012 en_US
dc.identifier.citation 191-200 en_US
dc.identifier.issn 0021-9797 en_US
dc.identifier.uri http://hdl.handle.net/2043/14293
dc.description.abstract The effect of pH on the build-up-of polyelectrolyte multilayers, PEMs, composed by poly-L-lysine and heparin onto two different substrates, silica and gold, has been studied by means of ellispmetry and quartz crystal microbalance with dissipation, QCM-D. Ellipsometry results indicate that the dry mass grows exponentially with the number of layers, and that this amount is larger as the pH values are raised. From QCM-D data the viscoelastic properties of the multilayered structure have been obtained. These data reflect that PEMs become more viscoelastic as the pH values are increased for silica substrates, while for gold the highest viscoelastic behavior is obtained at neutral pH and the elastic behavior becomes dominant as the pH is further increased or decreased. By combining these two surface techniques it has been also possible to determine the solvent content in the multilayers and reach a deeper understanding of the internal structure. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.subject Polyelectrolyte multilayers en_US
dc.subject Ellipsometry en_US
dc.subject QCM-D en_US
dc.subject Viscoelastic properties en_US
dc.subject Poly-L-lysine
dc.subject Heparin
dc.subject Viscoelasticity
dc.subject.classification Sciences en_US
dc.title Influence of pH on the build-up of poly-L-lysine/heparin multilayers en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society en
dc.identifier.doi http://dx.doi.org/10.1016/j.jcis.2012.08.008 en_US
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES en_US
dc.relation.ispartofpublication Journal of Colloid and Interface Science;1
dc.relation.ispartofpublicationvolume 388 en_US
dc.description.embargo 2015
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