Adsorption of lipid liquid crystalline nanoparticles on cationic, hydrophilic, and hydrophobic surfaces

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Adsorption of lipid liquid crystalline nanoparticles on cationic, hydrophilic, and hydrophobic surfaces

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dc.contributor.author Chang, Debby P.
dc.contributor.author Jankunec, Marija
dc.contributor.author Barauskas, Justas
dc.contributor.author Tiberg, Fredrik
dc.contributor.author Nylander, Tommy
dc.date Investigation of nonlamellar nanoparticles formed by dispersion of self-assembled lipid liquid crystalline phases is stimulated by their many potential applications in science and technology; resulting from their unique solubilizing, encapsulating, and space-dividing nature. Understanding the interfacial behavior of lipid liquid crystalline nanoparticles (LCNPs) at surfaces can facilitate the exploitation of such systems for a number of potentially interesting uses, including preparation of functional surface coatings and uses as carriers of biologically active substances. We have studied the adsorption of LCNP, based on phosphatidylcholine/glycerol dioleate and Polysorbate 80 as stabilizers, at different model surfaces by use of in situ ellipsometry. The technique allows time-resolved monitoring of the layer thickness and the amount adsorbed, thereby providing insights into the restructuring of the lipid nanoparticle upon adsorption. The effects of solvent condition, electrolyte concentration, particle size, and surface chemistry on adsorbed layer properties were investigated. Furthermore, the internal structures of the particles were investigated by cryo-transmission electron microscopy and small angle X-ray diffraction on the corresponding liquid crystalline phases in excess water. LCNPs are shown to form well-defined layers at the solid–liquid interface with a structure and coverage that are determined by the interplay between the self-assembly properties of the lipids and lipid surface interactions, respectively. At the hydrophobic surface, hydrophobic interaction results in a structural transition from the original LCNP morphology to a monolayer structure at the interface. In contrast, at cationic and hydrophilic surfaces, relaxation is a relatively slow process, resulting in much thicker adsorbed layers, with thickness and adsorption behavior that to a greater extent reflect the original bulk LCNP properties.
dc.date.accessioned 2012-11-02T08:27:00Z
dc.date.available 2012-11-02T08:27:00Z
dc.date.issued 2012 en_US
dc.identifier.citation 2643-2651 en_US
dc.identifier.issn 1944-8244 en_US
dc.identifier.uri http://hdl.handle.net/2043/14294
dc.description.abstract Investigation of nonlamellar nanoparticles formed by dispersion of self-assembled lipid liquid crystalline phases is stimulated by their many potential applications in science and technology; resulting from their unique solubilizing, encapsulating, and space-dividing nature. Understanding the interfacial behavior of lipid liquid crystalline nanoparticles (LCNPs) at surfaces can facilitate the exploitation of such systems for a number of potentially interesting uses, including preparation of functional surface coatings and uses as carriers of biologically active substances. We have studied the adsorption of LCNP, based on phosphatidylcholine/glycerol dioleate and Polysorbate 80 as stabilizers, at different model surfaces by use of in situ ellipsometry. The technique allows time-resolved monitoring of the layer thickness and the amount adsorbed, thereby providing insights into the restructuring of the lipid nanoparticle upon adsorption. The effects of solvent condition, electrolyte concentration, particle size, and surface chemistry on adsorbed layer properties were investigated. Furthermore, the internal structures of the particles were investigated by cryo-transmission electron microscopy and small angle X-ray diffraction on the corresponding liquid crystalline phases in excess water. LCNPs are shown to form well-defined layers at the solid–liquid interface with a structure and coverage that are determined by the interplay between the self-assembly properties of the lipids and lipid surface interactions, respectively. At the hydrophobic surface, hydrophobic interaction results in a structural transition from the original LCNP morphology to a monolayer structure at the interface. In contrast, at cationic and hydrophilic surfaces, relaxation is a relatively slow process, resulting in much thicker adsorbed layers, with thickness and adsorption behavior that to a greater extent reflect the original bulk LCNP properties.
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.subject silica-water interface en_US
dc.subject drug-delivery en_US
dc.subject cubic phase en_US
dc.subject ellipsometry en_US
dc.subject membranes en_US
dc.subject lipid liquid crystalline nanoparticle en_US
dc.subject cubosome en_US
dc.subject cationic en_US
dc.subject SPC en_US
dc.subject GDO en_US
dc.subject P80 en_US
dc.subject cryo-TEM en_US
dc.subject nanoparticles en_US
dc.subject.classification Sciences en_US
dc.title Adsorption of lipid liquid crystalline nanoparticles on cationic, hydrophilic, and hydrophobic surfaces en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society en
dc.identifier.doi http://dx.doi.org/10.1021/am300301b
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES en_US
dc.relation.ispartofpublication ACS Applied Materials and Interfaces;5
dc.relation.ispartofpublicationvolume 4 en_US
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