Adsorption of lipid liquid crystalline nanoparticles : effects of particle composition, internal structure, and phase behavior

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Adsorption of lipid liquid crystalline nanoparticles : effects of particle composition, internal structure, and phase behavior

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dc.contributor.author Chang, Debby P.
dc.contributor.author Jankunec, Marija
dc.contributor.author Barauskas, Justas
dc.contributor.author Tiberg, Fredrik
dc.contributor.author Nylander, Tommy
dc.date.accessioned 2012-11-02T08:27:10Z
dc.date.available 2012-11-02T08:27:10Z
dc.date.issued 2012 en_US
dc.identifier.citation 10688-10696 en_US
dc.identifier.issn 0743-7463 en_US
dc.identifier.uri http://hdl.handle.net/2043/14295
dc.description.abstract Controlling the interfacial behavior and properties of lipid liquid crystalline nanoparticles (LCNPs) at surfaces is essential for their application for preparing functional surface coatings as well as understanding some aspects of their properties as drug delivery vehicles. Here we have studied a LCNP system formed by mixing soy phosphatidylcholine (SPC), forming liquid crystalline lamellar structures in excess water, and glycerol dioleate (GDO), forming reversed structures, dispersed into nanoparticle with the surfactant polysorbate 80 (P80) as stabilizer. LCNP particle properties were controlled by using different ratios of the lipid building blocks as well as different concentrations of the surfactant P80. The LCNP size, internal structure, morphology, and charge were characterized by dynamic light scattering (DLS), synchrotron small-ange X-ray scattering (SAXS), cryo-transmission electron microscopy (cryo-TEM), and zeta potential measurements, respectively. With increasing SPC to GDO ratio in the interval from 35:65 to 60:40, the bulk lipid phase structure goes from reversed cubic micellar phase with Fd3m space group to reversed hexagonal phase. Adding P80 results in a successive shift toward more disorganized lamellar type of structures. This is also seen from cryo-TEM images for the LCNPs, where higher P80 ratios results in more extended lamellar layers surrounding the inner, more dense, lipid-rich particle core with nonlamellar structure. When put in contact with a solid silica surface, the LCNPs adsorb to form multilayer structures with a surface excess and thickness values that increase strongly with the content of P80 and decreases with increasing SPC:GDO ratio. This is reflected in both the adsorption rate and steady-state values, indicating that the driving force for adsorption is largely governed by attractive interactions between poly(ethylene oxide) (PEO) units of the P80 stabilizer and the silica surface. On cationic surface, i.e., silica modified with 3-aminopropltriethoxysilane (APTES), the slightly negatively charged LCNPs give rise to a very significant adsorption, which is relatively independent of LCNP composition. Finally, the dynamic thickness measurements indicate that direct adsorption of intact particles occurred on the cationic surface, while a slow buildup of the layer thickness with time is seen for the weakly interacting systems.
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.subject DRUG-DELIVERY APPLICATIONS en_US
dc.subject X-RAY-DIFFRACTION en_US
dc.subject CUBIC PHASE en_US
dc.subject HYDROPHOBIC SURFACES en_US
dc.subject WATER-INTERFACE en_US
dc.subject ELLIPSOMETRY en_US
dc.subject DISPERSIONS en_US
dc.subject MEMBRANES en_US
dc.subject.classification Sciences en_US
dc.title Adsorption of lipid liquid crystalline nanoparticles : effects of particle composition, internal structure, and phase behavior en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society en
dc.identifier.doi http://dx.doi.org/10.1021/la301579g
dc.subject.srsc Research Subject Categories::NATURAL SCIENCES en_US
dc.relation.ispartofpublication Langmuir;29
dc.relation.ispartofpublicationvolume 28 en_US
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