Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion.

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Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion.

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Publication Article, peer reviewed scientific
Title Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion.
Author(s) Stollenwerk, Maria Magdalena ; Lasson, Åke ; Andersson, Roland
Date 2012
English abstract
BACKGROUND: Intestinal ischemia and reperfusion (I/R) injury is a pivotal mechanism in critical illness and in the development of multiple organ dysfunction syndrome, in which the nuclear factor kappa B (NF-κB) activation plays a central role. Intestinal I/R injury initiates the extrinsic tissue factor or factor VIIa-dependent pathway of coagulation, also of importance in multiple organ dysfunction syndrome. Our aim was to analyze NF-κB activation in I/R injury in the rat intestine and in two main "shock" organs, that is, the liver and lungs. Pretreatment with active site-inactivated factor VII (FVIIai), an inhibitor of the extrinsic pathway, was evaluated.
DOI http://dx.doi.org/10.1016/j.jss.2012.07.056 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Journal of Surgical Research;2
Volume 178
ISSN 0022-4804
Pages 692–699
Language eng (iso)
Subject(s) Active site–inactivated factor VIIai
Factor VIIa
Intestine
Ischemia
Multiple organ failure
Nuclear factor kappa B
Reperfusion injury
Rat
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/14305 (link to this page)

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