Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion.

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Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion.

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dc.contributor.author Stollenwerk, Maria Magdalena
dc.contributor.author Lasson, Åke
dc.contributor.author Andersson, Roland
dc.date.accessioned 2012-11-08T11:31:43Z
dc.date.available 2012-11-08T11:31:43Z
dc.date.issued 2012 en_US
dc.identifier.citation 692–699 en_US
dc.identifier.issn 0022-4804 en_US
dc.identifier.uri http://hdl.handle.net/2043/14305
dc.description.abstract BACKGROUND: Intestinal ischemia and reperfusion (I/R) injury is a pivotal mechanism in critical illness and in the development of multiple organ dysfunction syndrome, in which the nuclear factor kappa B (NF-κB) activation plays a central role. Intestinal I/R injury initiates the extrinsic tissue factor or factor VIIa-dependent pathway of coagulation, also of importance in multiple organ dysfunction syndrome. Our aim was to analyze NF-κB activation in I/R injury in the rat intestine and in two main "shock" organs, that is, the liver and lungs. Pretreatment with active site-inactivated factor VII (FVIIai), an inhibitor of the extrinsic pathway, was evaluated. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.subject Active site–inactivated factor VIIai en_US
dc.subject Factor VIIa en_US
dc.subject Intestine en_US
dc.subject Ischemia en_US
dc.subject Multiple organ failure en_US
dc.subject Nuclear factor kappa B en_US
dc.subject Reperfusion injury en_US
dc.subject Rat en_US
dc.subject.classification Medicine en_US
dc.title Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion. en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Health and Society en
dc.identifier.doi http://dx.doi.org/10.1016/j.jss.2012.07.056 en_US
dc.subject.srsc Research Subject Categories::MEDICINE en_US
dc.relation.ispartofpublication Journal of Surgical Research;2
dc.relation.ispartofpublicationvolume 178
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