Novel implant coating agent promotes gene expression of osteogenic markers in rats during early osseointegration

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Novel implant coating agent promotes gene expression of osteogenic markers in rats during early osseointegration

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dc.contributor.author Bougas, Kostas
dc.contributor.author Jimbo, Ryo
dc.contributor.author Xue, Ying
dc.contributor.author Mustafa, Kamal
dc.contributor.author Wennerberg, Ann
dc.date.accessioned 2012-12-03T11:02:33Z
dc.date.available 2012-12-03T11:02:33Z
dc.date.issued 2012 en_US
dc.identifier.citation 9 en_US
dc.identifier.issn 1687-8787 en_US
dc.identifier.uri http://hdl.handle.net/2043/14453
dc.description.abstract The aim of this study was to evaluate the early bone response around laminin-1-coated titanium implants. Forty-five rats distributed in three equally sized groups were provided with one control (turned) and one test (laminin-1-coated) implant and were sacrificed after 3, 7, and 21 days. Real-time reverse-transcriptase polymerase chain reaction was performed for osteoblast markers (alkaline phosphatase, runt-related transcription factor 2, osteocalcin, type I collagen, and bone morphogenic protein 2), osteoclast markers (cathepsin K and tartrate-resistant acid phosphatase), inflammation markers (tumor necrosis factor α, interleukin 1β and interleukin 10), and integrin β1. Bone implant contact (BIC) and bone area (BA) were assessed and compared to the gene expression. After 3 days, the expression of bone markers was higher for the control group. After 7 days, the expression of integrin β1 and osteogenic markers was enhanced for the test group, while cathepsin K and inflammation markers were downregulated. No significant differences in BIC or BA were detected between test and control at any time point. As a conclusion, implant coating with laminin-1 altered gene expression in the bone-implant interface. However, traditional evaluation methods, as histomorphometry, were not adequately sensitive to detect such changes due to the short follow-up time. en_US
dc.language.iso eng en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.subject.classification Medicine en_US
dc.title Novel implant coating agent promotes gene expression of osteogenic markers in rats during early osseointegration en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology
dc.identifier.doi http://dx.doi.org/10.1155/2012/579274 en_US
dc.subject.srsc Research Subject Categories::ODONTOLOGY en_US
dc.relation.ispartofpublication International Journal of Biomaterials;579274
dc.relation.ispartofpublicationvolume 2012 en_US
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