Laminin coating promotes calcium phosphate precipitation on titanium discs in vitro

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Laminin coating promotes calcium phosphate precipitation on titanium discs in vitro

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dc.contributor.author Bougas, Kostas
dc.contributor.author Franke Stenport, Victoria
dc.contributor.author Tengvall, Pentti
dc.contributor.author Currie, Fredrik
dc.contributor.author Wennerberg, Ann
dc.date.accessioned 2012-12-03T11:19:21Z
dc.date.available 2012-12-03T11:19:21Z
dc.date.issued 2011 en_US
dc.identifier.citation 10 en_US
dc.identifier.issn 2029-283X en_US
dc.identifier.uri http://hdl.handle.net/2043/14454
dc.description.abstract Objectives: The objective of this study was to investigate the effect of a laminin coating on calcium phosphate precipitation on three potentially bioactive titanium surfaces in simulated body fluid. Material and Methods: Blasted titanium discs were prepared by alkali and heat treatment (AH), anodic oxidation (AO) or hydroxyapatite coating (HA) and subsequently coated with laminin. A laminin coated blasted surface (B) served as a positive control while a blasted non coated (B-) served as a negative control. Surface morphology was examined by Scanning Electron Microscopy (SEM). The analysis of the precipitated calcium and phosphorous was performed by Energy Dispersive X-ray Spectroscopy (EDX). Results: The thickness of the laminin coating was estimated at 26 Å by ellipsometry. Interferometry revealed that the coating process did not affect any of the tested topographical parameters on μm level when comparing B to B-. After 2 weeks of incubation in SBF, the alkali-heat treated discs displayed the highest calcium phosphate deposition and the B group showed higher levels of calcium phosphate than the B- group. Conclusions: Our results suggest that laminin may have the potential to be used as a coating agent in order to enhance the osseoinductive performance of biomaterial surfaces, with the protein molecules possibly functioning as nucleation centres for apatite formation. Nevertheless, in vivo studies are required in order to clarify the longevity of the coating and its performance in the complex biological environment. en_US
dc.language.iso eng en_US
dc.publisher Stilus Optimus en_US
dc.subject laminin en_US
dc.subject titanium en_US
dc.subject biomaterials en_US
dc.subject calcium phosphates en_US
dc.subject dental implants en_US
dc.subject osseointegration en_US
dc.subject.classification Medicine en_US
dc.title Laminin coating promotes calcium phosphate precipitation on titanium discs in vitro en_US
dc.type Article, peer reviewed scientific en_US
dc.contributor.department Malmö University. Faculty of Odontology
dc.identifier.doi http://dx.doi.org/10.5037/jomr.2011.2405 en_US
dc.subject.srsc Research Subject Categories::ODONTOLOGY en_US
dc.relation.ispartofpublication Journal of Oral and Maxillofacial Research;4
dc.relation.ispartofpublicationvolume 2 en_US
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