The immunobiology of aluminium adjuvants: how do they really work?

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The immunobiology of aluminium adjuvants: how do they really work?

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Publication Article, peer reviewed scientific
Title The immunobiology of aluminium adjuvants: how do they really work?
Author(s) Exley, Christopher ; Siesjö, Peter ; Eriksson, Håkan
Date 2010
English abstract
Aluminium adjuvants potentiate the immune response, thereby ensuring the potency and efficacy of typically sparingly available antigen. Their concomitant critical importance in mass vaccination programmes may have prompted recent intense interest in understanding how they work and their safety. Progress in these areas is stymied, however, by a lack of accessible knowledge pertaining to the bioinorganic chemistry of aluminium adjuvants, and, consequently, the inappropriate application and interpretation of experimental models of their mode of action. The objective herein is, therefore, to identify the many ways that aluminium chemistry contributes to the wide and versatile armoury of its adjuvants, such that future research might be guided towards a fuller understanding of their role in human vaccinations.
DOI http://dx.doi.org/10.1016/j.it.2009.12.009 (link to publisher's fulltext)
Host/Issue Trends in Immunolgy;3
Volume 31
ISSN 1471-4906
Pages 103-109
Language eng (iso)
Subject(s) vaccine
Al-adjuvant
Medicine
Research Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::Immunology
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Immunology::Immunobiology
Handle http://hdl.handle.net/2043/10137 (link to this page)

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