Dental pulp capping: effect of Emdogain Gel on experimentally exposed human pulps.

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Dental pulp capping: effect of Emdogain Gel on experimentally exposed human pulps.

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Publication Article, peer reviewed scientific
Title Dental pulp capping: effect of Emdogain Gel on experimentally exposed human pulps.
Author(s) Fransson, Helena ; Davies, Julia ; Holst, KE ; Schroder, Ulla ; Petersson, Kerstin
Date 2005
English abstract
AIM: To investigate the effect of Emdogain Gel (Biora AB, Malmo, Sweden), consisting of a enamel matrix derivative (EMD) in a propylene glycol alginate (PGA) vehicle, on experimentally exposed human pulps and to register postoperative symptoms. METHODOLOGY: Nine pairs of contralateral premolars scheduled for extraction on orthodontic indications were included. Following a superficial pulp amputation performed with a small (016) diamond bur, either EMDgel or a mix of calcium hydroxide and sterile saline was placed at random in contact with the pulp wound. The subjects made records of symptoms and were also interviewed about pain/discomfort by a blinded examiner. After 12 weeks the teeth were extracted, prepared and subjected to light microscopic examination in which the inflammation and newly formed hard tissue in the pulp were analysed. Immunohistochemistry was performed using affinity-purified rabbit anti-EMD polyclonal antibodies. RESULTS: Postoperative symptoms were less frequent in the EMDgel-treated than in the calcium hydroxide-treated teeth, especially during the first six weeks. In the EMDgel-treated teeth, new tissue partly filled the space initially occupied by the gel and hard tissue was formed alongside the exposed dentine surfaces and in patches in the adjacent pulp tissue. EMD was detected in the areas where new hard tissue had been formed. The wound area of the EMDgel-treated teeth exhibited inflammation in the majority of the teeth whereas less inflammation was seen in the calcium hydroxide-treated teeth where the hard tissue was formed as a bridge. CONCLUSIONS: In the EMDgel-treated teeth, postoperative symptoms were less frequent and the amount and pattern of hard tissue formation were markedly different than in the teeth treated with calcium hydroxide. However, the operative procedure and the formulation with EMD in a PGA vehicle do not seem to be effective for the formation of a hard tissue barrier.
DOI http://dx.doi.org/10.1111/j.1365-2591.2004.00932.x (link to publisher's fulltext)
Publisher Wiley
Host/Issue International Endodontic Journal;3
Volume 38
ISSN 0143-2885
Pages 186-194
Language eng (iso)
Subject(s) randomized controlled trial
calcium hydroxide
dental pulp exposure
dentinogenesis
histology
immunohistochemistry
Medicine
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology::Cell biology::Medical cell biology
Research Subject Categories::ODONTOLOGY::Endodontology
Handle http://hdl.handle.net/2043/11107 (link to this page)

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