Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes

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Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes

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Publication Article, peer reviewed scientific
Title Peak oxygen uptake in relation to total heart volume discriminates heart failure patients from healthy volunteers and athletes
Author(s) Engblom, Henrik ; Steding, katarina ; Carlsson, Marcus ; Mosén, Henrik ; Hedén, Bo ; Buhre, Torsten ; Ekmehag, Björn ; Arheden, Håkan
Date 2010
English abstract
Background An early sign of heart failure (HF) is a decreased cardiac reserve or inability to adequately increase cardiac output during exercise. Under normal circumstances maximal cardiac output is closely related to peak oxygen uptake (VO2peak) which has previously been shown to be closely related to total heart volume (THV). Thus, the aim of this study was to derive a VO2peak/THV ratio and to test the hypothesis that this ratio can be used to distinguish patients with HF from healthy volunteers and endurance athletes. Thirty-one patients with HF of different etiologies were retrospectively included and 131 control subjects (60 healthy volunteers and 71 athletes) were prospectively enrolled. Peak oxygen uptake was determined by maximal exercise test and THV was determined by cardiovascular magnetic resonance. The VO2peak/THV ratio was then derived and tested. Results Peak oxygen uptake was strongly correlated to THV (r2=0.74, p<0.001) in the control subjects, but not for the patients (r2=0.0002, p=0.95). The VO2peak/THV ratio differed significantly between control subjects and patients, even in patients with normal ejection fraction and after normalizing for hemoglobin levels (p<0.001). In a multivariate analysis the VO2peak/THV ratio was the only independent predictor of presence of HF (p<0.001). Conclusions The VO2peak/THV ratio can be used to distinguish patients with clinically diagnosed HF from healthy volunteers and athletes, even in patients with preserved systolic left ventricular function and after normalizing for hemoglobin levels.
DOI http://dx.doi.org/10.1186/1532-429X-12-74 (link to publisher's fulltext)
Host/Issue Journal of cardiovascular Magnetic Resonance;1
Volume 12
ISSN 1532-429X
Pages Article 74
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/11183 (link to this page)

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