A water gradient can be used to regulate drug transport across skin

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A water gradient can be used to regulate drug transport across skin

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Publication Article, peer reviewed scientific
Title A water gradient can be used to regulate drug transport across skin
Author(s) Björklund, Sebastian ; Engblom, Johan ; Thuresson, Krister ; Sparr, Emma
Date 2010
English abstract
At normal conditions there is a substantial water gradient over the skin as it separates the water-rich inside of the body from the dry outside. This leads to a variation in the degree of hydration from the inside to the outside of skin and changes in this gradient may affect its structure and function. In this study we raise the question: How do changes in the water gradient across skin affect its permeability? We approach this problem in novel diffusion experiments that permit strict control of the gradient in the chemical potential of water and hence well-defined boundary conditions. The results demonstrate that a water gradient can be used to regulate transport of drugs with different lipophilic characteristics across the skin barrier. It is shown that the transport of metronidazole (log Po/w=0.0) and methyl salicylate (log Po/w=2.5) across skin increases abruptly at low water gradients, corresponding to high degrees of skin hydration, and that this effect is reversible. This phenomenon is highly relevant to drug delivery applications due to its potential of temporarily open the skin barrier for transdermal drug delivery and subsequently close the barrier after treatment. Further, the results contribute to the understanding of the occlusion effect and indicate the boundary conditions of the water gradient needed to make use of this effect
DOI http://dx.doi.org/10.1016/j.jconrel.2010.01.005 (link to publisher's fulltext)
Publisher Elsevier B.V.
Host/Issue Journal of Controlled Release;2
Volume 143
ISSN 0168-3659
Pages 191-200
Language eng (iso)
Subject(s) stratum corneum
diffusive transport
flow-through cell
osmotic gradient
responding membrane
transdermal drug delivery
Research Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Dermatology and venerology
Research Subject Categories::NATURAL SCIENCES::Chemistry::Physical chemistry::Biophysical chemistry
Research Subject Categories::NATURAL SCIENCES::Chemistry::Physical chemistry::Surface and colloid chemistry
Handle http://hdl.handle.net/2043/11186 (link to this page)

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