Tramadol-induced oral dryness and pilocarpine treatment : effects on total protein and IgA.

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Tramadol-induced oral dryness and pilocarpine treatment : effects on total protein and IgA.

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Publication Article, peer reviewed scientific
Title Tramadol-induced oral dryness and pilocarpine treatment : effects on total protein and IgA.
Author(s) Looström, H ; Akerman, Sigvard ; Ericson, Dan ; Tobin, G ; Götrick, Bengt
Date 2011
English abstract
Pilocarpine induces a profuse flow of saliva, and it may re-establish saliva production in cases of drug-induced oral dryness. The aim of the study (a sub-study to the previous trial investigating the pilocarpine fluid effects in individuals suffering from drug-induced dry mouth) was to search for saliva quality changes induced by the treatments. Sixty-five individuals were enrolled in a randomized, double-blind, placebo-controlled trial. The subjects received tramadol to induce oral dryness. Secretion rate was measured before and after tramadol, and then after pilocarpine, placebo, or no treatment. All saliva was analyzed for its protein and IgA content in the pilocarpine (n=15) and placebo groups (n=12). At baseline, the flow of saliva was 0.47±0.05ml/min, the protein output 0.17±0.2mg/min and the IgA output 0.022±0.002mg/min. After tramadol treatment (50mg 3×/day over two days), the flow was reduced by 64%, protein output by 52% and the IgA output by 38%. While placebo treatment did not affect any of the variables, the flow was 120%, the protein output 193% and the IgA output 83% of the baseline characteristics after pilocarpine treatment (5mg). Thus, the pilocarpine-induced increase in the flow rate in the state of tramadol-induced oral dryness results in saliva with a well preserved protein concentration but with a decrease in IgA concentration. However, compared to baseline, there was neither a decrease in output nor in concentration of IgA.
DOI http://dx.doi.org/10.1016/j.archoralbio.2010.10.019 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Archives of Oral Biology;4
Volume 56
ISSN 0003-9969
Pages 395-400
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/12434 (link to this page)

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