Detection of suPAR in the saliva of healthy young adults: comparison with plasma levels

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Detection of suPAR in the saliva of healthy young adults: comparison with plasma levels

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Publication Article, peer reviewed scientific
Title Detection of suPAR in the saliva of healthy young adults: comparison with plasma levels
Author(s) Gustafsson, Anna ; Ajeti, Vjosa ; Ljunggren, Lennart
Date 2011
English abstract
The soluble urokinase plasminogen activator receptor (suPAR) has been detected in blood, plasma, serum, urine, ovarian cystic fluid, and cerebrospinal fluid. Elevated suPAR levels in plasma have been associated with negative outcomes in various diseases, such as bacteremia, sepsis, SIRS, cardiovascular disease, cancer, and tuberculosis. The primary aim of this study was to investigate whether suPAR can be detected in saliva from healthy individuals and thus, if saliva suPAR can be related to plasma suPAR, CRP, BMI, or gender. Blood and unstimulated whole saliva was collected from 20 healthy individuals (10 female and 10 male, median age of 28 years; range 21–41). CRP and suPAR were measured with ELISA in saliva and serum/plasma. suPAR was detected in all saliva samples in the 5.2–28.1 ng/mL range, with a median value of 17.1 ng/mL. Saliva suPAR was significantly higher (P , 0.001) but not correlated to plasma suPAR in healthy young adults with normal plasma suPAR levels. suPAR and CRP levels were correlated in blood but not in saliva. No correlation was found between BMI, age, or gender and suPAR in saliva.
DOI http://dx.doi.org/10.4137/BMI.S8326 (link to publisher's fulltext)
Publisher Libertas Academica
Host/Issue Biomarker insights;6
Volume 2011
ISSN 1177-2719
Pages 119-125
Language eng (iso)
Subject(s) plasma suPAR
saliva biomarkers
saliva CRP
saliva suPAR
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/12612 (link to this page)

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