High disaccharide intake associates with atherogenic lipoprotein profile

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High disaccharide intake associates with atherogenic lipoprotein profile

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Publication Article, peer reviewed scientific
Title High disaccharide intake associates with atherogenic lipoprotein profile
Author(s) Sonestedt, Emily ; Wirfält, Elisabet ; Wallström, Peter ; Gullberg, Bo ; Drake, Isabel ; Hlebowicz, Joanna ; Nordin Fredrikson, Gunilla ; Hedblad, Bo ; Nilsson, Jan ; Krauss, Ronald ; Orhu-Melander, Marju
Date 2012
English abstract
Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46–68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol.
DOI http://dx.doi.org/10.1017/S0007114511003783 (link to publisher's fulltext)
Publisher Cambridge
Host/Issue British Journal of Nutrition;7
Volume 107
ISSN 1475-2662
Pages 1062-9
Language eng (iso)
Subject(s) Macronutrients
Atherogenic lipoprotein phenotype
Lipoprotein subfractions
Epidemiology
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/12829 (link to this page)

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