Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults

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Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults

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Publication Article, peer reviewed scientific
Title Glycoprotein 340 and sialic acid in minor-gland and whole saliva of children, adolescents, and adults
Author(s) Sonesson, Mikael ; Ericson, Dan ; Kinnby, Bertil ; Wickström, Claes
Date 2011
English abstract
Glycoprotein 340 (gp-340) is a bacterial-binding glycoprotein observed in major and minor gland saliva. Sialic acid, a common terminal structure of salivary glycoproteins, interacts with microorganisms and host ligands, as well as free radicals. This study investigated the content of gp-340 and sialic acid in minor gland and whole saliva of children (3-yr-olds), adolescents (14-yr-olds) and adults (20 to 25-yr-olds). Labial and buccal gland saliva was collected on filter paper and un-stimulated whole saliva by draining into a tube. The relative amount of gp-340 and sialic acid was determined by ELISA and ELLA, respectively. In minor gland saliva, no statistically significant differences in gp-340 and sialic acid were seen between the age-groups. Significantly lower amounts of gp-340 and sialic acid were seen in labial saliva compared to buccal among adults (P < 0.05, P < 0.01). In whole saliva, the amount of gp-340 was significantly lower among adults compared to children (P < 0.01). No differences between genders were seen. Stable gp-340 and sialic acid contents in minor-gland saliva across the age-groups and higher gp-340 content in the whole saliva of the youngest age-group (3-yr-olds) compared with the adult-group may reflect a vital innate factor of immunity in children’s saliva.
DOI http://dx.doi.org/10.1111/j.1600-0722.2011.00879.x (link to publisher's fulltext)
Publisher Wiley
Host/Issue European Journal of Oral Sciences;119
Volume 6
ISSN 0909-8836
Pages 435-40
Language eng (iso)
Subject(s) age
gp-340
minor gland
saliva
sialic acid
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/12998 (link to this page)

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