Oral pigmentation in the hard palate associated with imatinib mesylate therapy: a report of three cases

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Oral pigmentation in the hard palate associated with imatinib mesylate therapy: a report of three cases

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Publication Article, peer reviewed scientific
Title Oral pigmentation in the hard palate associated with imatinib mesylate therapy: a report of three cases
Author(s) Mattsson, Ulf ; Halbritter, Sandro ; Mörner Serikoff, Elisabeth ; Christerson, Lars ; Warfvinge, Gunnar
Date 2011
English abstract
Imatinib mesylate is a tyrosine kinase inhibitor which targets Bcr-Abl-protein, c-Kit, and platelet-derived growth factor receptor. The drug was originally developed for treatment of chronic myeloid leukemia but is also regarded as first-line treatment of patients with metastatic gastrointestinal stromal tumours (GIST). Dermatologic side effects are common, with superficial edema and rash as the most frequent. In addition, imatinib mesylate treatment is often associated with hypopigmentation. Intraoral side effects are very rare. The present paper demonstrates 1 patient with GIST and 2 patients with chronic myeloid leukemia treated with imatinib mesylate for 5-6 years. All 3 patients presented with diffuse solitary bluish-brown pigmentations in the hard palate. The lesions persisted at follow-ups. There were no other pigmentations in the oral mucosa. The histopathologic examination showed depositions of melanin pigment in the lamina propria. The possible relationship between the observed melanotic maculae and imatinib mesylate treatment is discussed.
DOI http://dx.doi.org/10.1016/j.tripleo.2010.11.006 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology;5
Volume 111
ISSN 1079-2104
Pages e12-e16
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/13146 (link to this page)

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