Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties

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Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties

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Publication Article, peer reviewed scientific
Title Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties
Author(s) Jimbo, Ryo ; Coelho, Paulo G ; Bryington, Matthew ; Baldassarri, Marta ; Tovar, Nick ; Currie, Fredrik ; Hayashi, Mariko ; Janal, Malvin N ; Andersson, Martin ; Ono, Daisuke ; Vandeweghe, Stefan ; Wennerberg, Ann
Date 2012
English abstract
Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.
DOI http://dx.doi.org/10.1177/0022034512463240 (link to publisher's fulltext)
Publisher Sage
Host/Issue Journal of Dental Research;12
Volume 91
ISSN 0022-0345
Pages 1172-1177
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/14714 (link to this page)

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