Transferrin receptor in children and its correlation with iron status and types of milk consumption

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Transferrin receptor in children and its correlation with iron status and types of milk consumption

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Publication Article, peer reviewed scientific
Title Transferrin receptor in children and its correlation with iron status and types of milk consumption
Author(s) Bramhagen, Ann-Cathrine ; Virtanen, M ; Siimes, MA ; Axelsson, Irene
Date 2003
English abstract
Aim: This study compared transferrin receptor (TfR) concentrations with iron parameters relative to a child´s intake of cow´s milk and follow-on formula. Methods: TfR, β-Haemoglobin, serum ferritin and mean corpuscular volume (MCV) of red blood cells were analyzed in a study population of 263 children aged 2.5 y. The amount of cow´s milk and follow-on formula consumed were recorded. Results: There was a significant difference of TfR/log. ferritin between children whose milk intake was < 500 ml and those with a milk intake of > 500 ml (p=0.003). There were significantly higher values of TfR/log. ferritin in children whose MCV of red blood cells was < 75fL than those with > 75fL (p=<0.0001). The TfR concentrations were significantly lower after iron treatment. Conclusion: Higher concentrations of TfR were correlated with lower concentrations of haemoglobin and MCV of red blood cells. Milk consumption increases the risk of higher ratio of TfR/log. ferritin. TfR concentrations were significantly lower after iron treatment.
Swedish abstract
Syfte: Denna studie jämförde koncentrationen av transferrin receptor (TfR) med järnstatus parametrar i relation till barnets intag av komjölk och välling. Metod: TfR, β-Haemoglobin, serum ferritin och medelcellsvolumen (MCV) på de röda blodkropparna analyserades i en population av 263 barn i åldern 2.5 år. Mängden komjölk och välling som barnet drack registrerades. Resultat: Det fanns en signifikant skillnad i TfR/log. ferritin mellan barn vars intag av komjölk var < 500 ml respektive barn med intag av mjölk > 500 ml (p= 0.003). Där fanns ett signifikant högre värde av TfR/log. ferritin bland barn med en medelscellsvolum av de röda blodkropparna på < 75fL jämfört med de som hade > 75fL (p=<0.0001). Koncentrationen av TfR var signifikant högre efter järnbehandling. Konklusion: Högre koncentrationer av TfR var korrelerade med lägre koncentrationer av haemoglobin och MCV av röda bloda kroppar. Mjölk konsumtion ökade risken för högre kvot av TfR/log ferritin. TfR koncentrationen var signifikant lägre efter järnbehandling.
DOI http://dx.doi.org/10.1111/j.1651-2227.2003.tb00597.x (link to publisher's fulltext)
Publisher Taylor & Francis
Host/Issue Acta Paediatrica;6
Volume 92
ISSN 0803-5253
Pages 671-675
Language eng (iso)
Subject(s) children
cow´s milk
iron
transferrin receptor
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/14862 (link to this page)

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