Elevated levels of salivary lactoferrin, a marker for chronic periodontitis?

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Elevated levels of salivary lactoferrin, a marker for chronic periodontitis?

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Publication Article, peer reviewed scientific
Title Elevated levels of salivary lactoferrin, a marker for chronic periodontitis?
Author(s) Glimvall, Pontus ; Wickstrom, Claes ; Jansson, Henrik
Date 2012
English abstract
Background and Objective: Whole saliva is a complex mixture of fluids essential for the well-being of the oral hard and soft tissues. Saliva contains numerous anti- microbial proteins that help protect the oral ecosystem from infectious agents. Chronic periodontitis is an infectious chronic inflammatory condition that affects the tooth-supporting structures and leads to their destruction. The aim of the present study was to investigate differences in concentrations of salivary lacto- ferrin in subjects with and without periodontal disease and correlate these values with clinical variables associated with periodontal disease. Material and Methods: Stimulated whole saliva was collected from 17 subjects with chronic periodontitis and 17 periodontally healthy control subjects. Data relating to bleeding on probing, probing pocket depth and horizontal bone loss were registered. Concentrations of lactoferrin, lysozyme and IgA in stimulated whole saliva were quantified using ELISA. Results: Subjects with chronic periodontits showed higher concentrations of lac- toferrin in stimulated whole saliva compared with periodontally healthy control subjects (p < 0.05). Salivary concentrations of lactoferrin were positively corre- lated with bleeding on probing (p < 0.001) and the number of sites with probing pocket depth ‡ 6 mm (p < 0.001). Conclusion: Lactoferrin is raised in stimulated whole saliva in subjects with chronic periodontitis and is correlated with probing pocket depth ‡ 6 mm.
DOI http://dx.doi.org/10.1111/j.1600-0765.2012.01479.x (link to publisher's fulltext)
Publisher John Wiley and Sons
Host/Issue Journal of Periodontal Research;5
Volume 47
ISSN 0022-3484
Pages 655–660
Language eng (iso)
Subject(s) lactoferrin
periodontitis
saliva
diagnostic marker
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/14979 (link to this page)

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