Bone apposition to laminin-1 coated implants : histologic and 3D evaluation

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Bone apposition to laminin-1 coated implants : histologic and 3D evaluation

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Publication Article, peer reviewed scientific
Title Bone apposition to laminin-1 coated implants : histologic and 3D evaluation
Author(s) Bougas, Kostas ; Jimbo, Ryo ; Vandeweghe, Stefan ; Hayashi, Mariko ; Bryington, Matthew ; Kozai, Yusuke ; Schwartz-Filho, Humberto O ; Tovar, Nick ; Adolfsson, Erik ; Ono, Daisuke ; Coelho, Paulo G ; Wennerberg, Ann
Date 2013
English abstract
Laminin-1 has been reported as one of the factors responsible for the nucleation of calcium phosphates and, in vitro, has been reported to selectively recruit osteoprogenitors. This article focused on its in vivo effects, and evaluated the effect of laminin-1 local application on osseointegration. Polished cylindrical hydroxyapatite implants were coated with laminin-1 (test) and the bone responses in the rabbit tibiae after 2 and 4 weeks were evaluated and compared to the non-coated implants (control). Before the samples were processed for histological sectioning, they were three-dimensionally analysed with micro computed tomography (μCT). Both evaluation methods were analysed with regards to bone area around the implant and bone to implant contact. From the histologic observation, new bone formation around the laminin-1 coated implant at 2 weeks seemed to have increased the amount of supporting bone around the implant, however, at 4 weeks, the two groups presented no notable differences. The two-dimensional and three-dimensional morphometric evaluation revealed that both histologic and three-dimensional analysis showed some tendency in favour of the test group implants, however there was no statistical significance between the test and control group results.
DOI (link to publisher's fulltext)
Publisher Elsevier
Host/Issue International Journal of Oral and Maxillofacial Surgery;5
Volume 42
ISSN 0901-5027
Pages 677-682
Language eng (iso)
Subject(s) laminin
animal experiments
micro CT
bone implant interactions
Research Subject Categories::ODONTOLOGY
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