Low expression of SHP-2 is associated with less favorable prostate cancer outcomes

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Low expression of SHP-2 is associated with less favorable prostate cancer outcomes

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Publication Article, peer reviewed scientific
Title Low expression of SHP-2 is associated with less favorable prostate cancer outcomes
Author(s) Tassidis, Helena ; Brokken, Leon JS ; Jirström, Karin ; Bjartell, Anders ; Ulmert, David ; Härkönen, Pirkko ; Gjörloff Wingren, Anette
Date 2013
English abstract
Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because of its ability to dephosphorylate receptors of growth factors as well as the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In the current study, we used four different prostate cancer cell lines: PC3, DU145, LNCaP and LNCaP-IL6+. Tumor specimens from 122 patients with prostate cancer were analyzed using a tissue microarray. Our data demonstrate that all four prostate cancer cell lines express the SHP-2 protein. Additionally, low staining intensity and SHP-2 expression in the cytoplasm of cancer cells in prostate tumor specimens was inversely correlated with prostate volume (p = 0.041 and p = 0.042, respectively) whereas nuclear staining was positively correlated with extracapsular extension (p = 0.039). In our post-prostatectomy specimens, we found that patients with low SHP-2 expression had less favorable outcomes with respect to biochemical recurrence and clinical progression (p = 0.005 and p = 0.018, respectively). The loss of cytoplasmic SHP-2 expression is associated with increased growth and prostatic cancer progression.
DOI http://dx.doi.org/10.1007/s13277-012-0590-1 (link to publisher's fulltext)
Publisher Springer
Host/Issue Tumor Biology;2
Volume 34
ISSN 1010-4283
Pages 637-642
Language eng (iso)
Subject(s) Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2)
Prostate cancer
Tissue microarray (TMA)
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/15377 (link to this page)

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