Are Botulinum Toxin Injections Into the Major Salivary Glands a Good Treatment Option?

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Are Botulinum Toxin Injections Into the Major Salivary Glands a Good Treatment Option?

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Publication Article, peer reviewed scientific
Title Are Botulinum Toxin Injections Into the Major Salivary Glands a Good Treatment Option?
Author(s) Nordgarden, Hilde ; Østerhus, Ingvild ; Møystad, Anne ; Åsten, Pamela ; Johnsen, Ulf L-H ; Storhaug, Kari ; Loven, Jens Øyvind
Date 2012
English abstract
There are several treatment options available for drooling; botulinum toxin injections into the major salivary glands are one. There is no consensus as to how many and which glands should be injected. A research project on this topic was terminated because of adverse effects. Individual results and the adverse effects are described and discussed in this article. Six individuals with cerebral palsy were randomly allocated to 2 treatment groups, with five individuals receiving ultrasound-guided injections to parotid and submandibular glands and one receiving injections to the submandibular glands only. Reduction of observed drooling was registered in 3, while 4 patients reported subjective improvement (Visual Analog Scale). Two participants reported adverse effects, including dysphagia, dysarthria, and increased salivary viscosity. Injections with botulinum toxin can be a useful treatment option but there is a risk of adverse effects. Multidisciplinary evaluation and informed discussions with patients/caregivers are important factors in the decision-making process.
DOI http://dx.doi.org/10.1177/0883073811419365 (link to publisher's fulltext)
Publisher Sage
Host/Issue Journal of Child Neurology;4
Volume 27
ISSN 0883-0738
Pages 458-464
Language eng (iso)
Subject(s) disability
adverse effects
mouth
drooling
botulinum toxin
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/15647 (link to this page)

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