Immunocytokines : a review of molecules in clinical development for cancer

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Immunocytokines : a review of molecules in clinical development for cancer

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Publication Article, peer reviewed scientific
Title Immunocytokines : a review of molecules in clinical development for cancer
Author(s) List, Thomas ; Neri, Dario
Date 2013
English abstract
The concept of therapeutically enhancing the immune system's responsiveness to tumors is long standing. Several cytokines have been investigated in clinical trials for their therapeutic activity in cancer patients. However, substantial side effects and unfavorable pharmacokinetic properties have been a major drawback hampering the administration of therapeutically relevant doses. The use of recombinant antibody-cytokine fusion proteins promises to significantly enhance the therapeutic index of cytokines by targeting them to the site of disease. This review aims to provide a concise and complete overview of the preclinical data and clinical results currently available for all immunocytokines having reached clinical development.
DOI http://dx.doi.org/10.2147/CPAA.S49231 (link to publisher's fulltext)
Publisher Dove Press
Host/Issue Clinical pharmacology : advances and applications;
Volume 5
ISSN 1179-1438
Pages 29-45
Language eng (iso)
Subject(s) antibodies
cytokines
preclinical
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/15900 (link to this page)

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