Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons

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Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons

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Publication Article, peer reviewed scientific
Title Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons
Author(s) Andoralov, Viktor ; Falk, Magnus ; Suyatin, Dmitry ; Granmo, Marcus ; Sotres, Javier ; Ludwig, Roland ; Popov, Vladimir ; Schouenborg, Jens ; Blum, Zoltan ; Sergey, Shleev
Date 2013
English abstract
Miniature, self-contained biodevices powered by biofuel cells may enable a new generation of implantable, wireless, minimally invasive neural interfaces for neurophysiological in vivo studies and for clinical applications. Here we report on the fabrication of a direct electron transfer based glucose/oxygen enzymatic fuel cell (EFC) from genuinely three-dimensional (3D) nanostructured microscale gold electrodes, modified with suitable biocatalysts. We show that the process underlying the simple fabrication method of 3D nanostructured electrodes is based on an electrochemically driven transformation of physically deposited gold nanoparticles. We experimentally demonstrate that mediator-, cofactor-, and membrane-less EFCs do operate in cerebrospinal fluid and in the brain of a rat, producing amounts of electrical power sufficient to drive a self-contained biodevice, viz. 7 μW cm−2 in vitro and 2 μW cm−2 in vivo at an operating voltage of 0.4 V. Last but not least, we also demonstrate an inductive coupling between 3D nanobioelectrodes and living neurons.
DOI http://dx.doi.org/10.1038/srep03270 (link to publisher's fulltext)
Link http://www.nature.com/srep/2013/131120/srep03270/full/srep03270.html (external link to publication)
Publisher Nature Publishing Group
Host/Issue Scientific Reports;3
ISSN 2045-2322
Pages art. 3270
Language eng (iso)
Subject(s) Neuroscience
Immobilized enzymes
Bioanalytical chemistry
Chemical physics
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/16367 (link to this page)

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