Salivary IgA response to probiotic bacteria and mutans streptococci after the use of chewing gum containing Lactobacillus reuteri

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Salivary IgA response to probiotic bacteria and mutans streptococci after the use of chewing gum containing Lactobacillus reuteri

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Publication Article, peer reviewed scientific
Title Salivary IgA response to probiotic bacteria and mutans streptococci after the use of chewing gum containing Lactobacillus reuteri
Author(s) Ericson, Dan ; Hamberg, Kristina ; Bratthall, Gunilla ; Sinkiewicz-Enggren, Gabriela ; Ljunggren, Lennart
Date 2013
English abstract
We investigated whether ingestion of probiotic bacteria could influence salivary IgA levels, specific anti-mutans streptococci IgA levels and specific antibodies towards the ingested probiotic bacterium. The study was a randomised, double-blind, placebo-controlled trial, where the test group (n = 11) received twice daily chewing of gum containing Lactobacillus reuteri (2 9 108 CFU per dose) and the control group (n = 12) received placebo. Resting saliva was collected before and after 12 weeks of treatment and 4 weeks after end of treatment. Total salivary IgA concentrations were measured by ELISA. Specific IgA reactivity was determined using a whole-cell ELISA. Results were expressed as % IgA per protein in saliva. The level of total IgA% per protein increased significantly between pretreatment levels (13.5%) and follow-up treatment levels (14.4%) within the test group only (P < 0.05). No changes were seen in the control group during the trial. The level of probiotic-reactive antibodies decreased significantly between pre- and post-treatment samples (from 12.2% to 9.0%, P < 0.05) in the test group. Similarly, the level of specific mutans streptococci antibodies decreased significantly between pre- and post-treatment samples (P < 0.05) in the test group only (for Streptococcus mutans from 20.1% to 15.0%; for Streptococcus sobrinus from 7.4% to 5.3%). Ingestion of probiotic bacteria might influence the adaptive immune response of the host.
DOI http://dx.doi.org/10.1111/2049-632X.12048 (link to publisher's fulltext)
Publisher Wiley Blackwell
Host/Issue Pathogens and Disease;3
Volume 68
ISSN 2049-632X
Pages 82-87
Language eng (iso)
Subject(s) probiotics
salivary IgA
mutans streptococci
Lactobacillus reuteri
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/16387 (link to this page)

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