Flexible micro(bio)sensors for quantitative analysis of bioanalytes in a nanovolume of human lachrymal liquid

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Flexible micro(bio)sensors for quantitative analysis of bioanalytes in a nanovolume of human lachrymal liquid

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Publication Article, peer reviewed scientific
Title Flexible micro(bio)sensors for quantitative analysis of bioanalytes in a nanovolume of human lachrymal liquid
Author(s) Andoralov, Viktor ; Shleev, Sergey ; Arnebrant, Thomas ; Ruzgas, Tautgirdas
Date 2013
English abstract
A flexible electrochemical micro(bio)sensor has been designed for determination of several biological compounds, specifically, ascorbate, dopamine, and glucose, in human lachrymal liquid (tears). The microsensor for simultaneous determination of ascorbate and dopamine concentrations was based on a gold microwire modified with the tetrathiafulvalen–7,7,8,8-tetracyanoquinodimethane complex as a catalyst. To monitor glucose concentration in tears, glucose dehydrogenase was immobilized on a gold microwire modified with carbon nanotubes and an osmium redox polymer. A capillary microcell was constructed for sampling tears. The cell had a working volume of 60–100 nL with a sampling deviation of 6.7 %. To check if the microcell was properly filled with buffer or tear sample, a control electrode was introduced into the construction. The electrode was used to measure the electrical resistance of a fully filled nanovolume cell. The mechanical flexibility is one of the most important features of the prototype and allowed direct collection of tears with minimized risk of damage to the eye.
Link http://link.springer.com/article/10.1007%2Fs00216-013-6756-x#page-1 (external link to publication)
Publisher Springer
Host/Issue Anal Bioanal Chem;11
Volume 405
ISSN 1618-2642
Pages 3871-3879
Language eng (iso)
Subject(s) Flexible micro(bio)sensor
Nanovolume
Tears
Ascorbate
Dopamine
Glucose
Medicine
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/16436 (link to this page)

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