Nonlamellar lipid liquid crystalline model surfaces for biofunctional studies

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Nonlamellar lipid liquid crystalline model surfaces for biofunctional studies

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Publication Article, peer reviewed scientific
Title Nonlamellar lipid liquid crystalline model surfaces for biofunctional studies
Author Wadsäter, Maria ; Barauskas, Justas ; Nylander, Tommy ; Tiberg, Fredrik
Date 2013
English abstract
Nonlamellar lipid liquid crystalline (LC) bulk phases and dispersions show promise as functional nanostructured materials for potential use as controlled release matrices e. g. in pharmaceuticals. Herein, methods for preparing and characterizing thin films of lipid liquid crystalline phases on solid surfaces are presented. The thickness, hydration phase structure and surface topography of spin-coated films of mixtures of soy phosphatidylcholine and glycerol dioleate are characterized by means of spectroscopic ellipsometry, small angle X-ray diffraction and atomic force microscopy. Besides being useful as bioadhesive drug delivery systems, the lipid nonlamellar LC films produced may also be exploited as model surfaces for studying properties such as bioadhesion and biodegradation.
DOI http://dx.doi.org/10.1039/c3sm51385h (link to publisher's fulltext)
Publisher Royal Society of Chemistry
Host/Issue Soft Matter;37
Volume 9
ISSN 1744-683X
Pages 8815-8819
Language eng (iso)
Subject CUBIC PHASE
NANOPARTICLES
FILMS
PHOSPHATIDYLCHOLINE
MEMBRANES
MICELLES
BILAYERS
LIPIDS
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/16451 Permalink to this page
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