Water Sorption and Glass Transition of Pig Gastric Mucin Studied by QCM-D

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Water Sorption and Glass Transition of Pig Gastric Mucin Studied by QCM-D

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Publication Article, peer reviewed scientific
Title Water Sorption and Glass Transition of Pig Gastric Mucin Studied by QCM-D
Author(s) Znamenskaya, Yana ; Sotres, Javier ; Gavryushov, Sergei ; Engblom, Johan ; Arnebrant, Thomas ; Kocherbitov, Vitaly
Date 2013
English abstract
Hydration of films of pig gastric mucin was studied using a quartz crystal microbalance with dissipation monitoring (QCM-D) equipped with a humidity module. As a prerequisite, the water adsorption isotherm of a clean silica surface was determined. Atomic force microscopy was used to characterize the changes occurring on the silica surface after repeated sorption/desorption and cleaning cycles. The water sorption isotherms of several hundreds of nanometers thick mucin films were obtained in QCM-D experiments using analysis of overtone behavior. The results show that the sorption isotherms are not dependent on the film thicknesses and are in good agreement with sorption calorimetric data on mucin in the bulk phase. Moreover, hydration-induced changes of rheological properties of mucin films were investigated using a model-free approach. The ratio of G′/G″ was evaluated as a function of relative humidity. The transition from solidlike behavior to liquidlike behavior was observed in the same humidity range as in sorption calorimetric experiments. Thus, ability of QCM-D to monitor glass transition in biopolymers was demonstrated.
DOI http://dx.doi.org/10.1021/jp311968b (link to publisher's fulltext)
Publisher American Chemical Society ACS
Host/Issue Journal of Physical Chemistry B;8
Volume 117
ISSN 1520-6106
Pages 2554–2563
Language eng (iso)
Subject(s) Hydration
Glass transition
Sorption Calorimetry
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/16488 (link to this page)

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