The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria

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The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria

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Publication Article, peer reviewed scientific
Title The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria
Author(s) Naito, Yoshihito ; Terukina, Takayuki ; Galli, Silvia ; Kozai, Yusuke ; Vandeweghe, Stefan ; Tagami, Tatsuaki ; Ozeki, Tetsuya ; Ichikawa, Tetsuo ; Coelho, Paulo ; Jimbo, Ryo
Date 2014
English abstract
The present study describes the development of a microsphere capsule based on polylactide-co-glycolide (PLGA) loaded with simvastatin that was subsequently incorporated into synthetic bone cement. The osteogenic effect of simvastatin-loaded bone cement was in a critical sized defect in vivo to test the hypothesis the biologic response would be different depending on the dosage of simvastatin applied to bone cement. Our results showed that simvastatin loaded PLGA microspheres can be successfully obtained through O/W emulsion/solvent evaporation method with appropriate morphologic characteristics and high encapsulation efficiency for incorporation in bone cements. The biodegradable characteristic of the microspheres successfully presented a slow release and the duration of the release lasted for more than 1 month. The in vivo experiment revealed that the microspheres containing simvastatin significantly enhanced bone formation in the rabbit calvaria critical size defect.
DOI http://dx.doi.org/10.1016/j.ijpharm.2013.11.046 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue International Journal of Pharmacology;1-2
Volume 461
ISSN 0378-5173
Pages 157–162
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/16745 (link to this page)

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