Effects of locally administered insulin on bone formation in non-diabetic rats

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Effects of locally administered insulin on bone formation in non-diabetic rats

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Publication Article, peer reviewed scientific
Title Effects of locally administered insulin on bone formation in non-diabetic rats
Author(s) Malekzadeh, Benoosh ; Tenvall, Pentti ; Öhrnell, LO ; Wennerberg, Ann ; Westerlund, A
Date 2013
English abstract
The possibility to control bone formation would be favorable in many areas of medicine, where bone defects is still a major challenge. Insulin has been suggested to exert both systemic and local anabolic effects in bone tissues. This raised the question whether locally administrated insulin could provide new therapeutic strategies for patients with local bone defects and impaired bone healing. The aim of this study was to evaluate bone formation in non-diabetic rats when local insulin is administered. This study differs from previous reports in two aspects: the use of non-diabetic animals and locally administered insulin. Twenty-four implants were inserted into 12 rats-one insulin-coated and one control-in each tibia for four weeks. Interferometry and histomorphometry were used to evaluate the surface topography and bone formation, respectively. Results demonstrated no significant changes in surface topography after insulin immobilization. Histomorphometry revealed significantly more bone around the insulin-coated implants (BA) (p = 0.005) and a similar amount of bone at the implant surface (BIC) (p = 0.117) compared with the controls. It was concluded that locally administered insulin from a titanium implant surface has the potential to increase bone formation not only in diabetic subjects but also in non-diabetic subjects.
DOI http://dx.doi.org/10.1002/jbm.a.34313 (link to publisher's fulltext)
Publisher Wiley
Host/Issue Journal of Biomedical Materials Research A;1
Volume 101A
ISSN 1552-4965
Pages 132–137
Language eng (iso)
Subject(s) insulin
slow release
implant
drug delivery
bone
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/16762 (link to this page)

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