Autoantibodies and gastrointestinal symptoms in infertile women in relation to in vitro fertilization

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Autoantibodies and gastrointestinal symptoms in infertile women in relation to in vitro fertilization

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Publication Article, peer reviewed scientific
Title Autoantibodies and gastrointestinal symptoms in infertile women in relation to in vitro fertilization
Author(s) Hammar, Oskar ; Roth, Bodil ; Bengtsson, Mariette ; Mandl, Thomas ; Ohlsson, Bodil
Date 2013
English abstract
BACKGROUND: Prior reports suggest a link between gonadotropin-releasing hormone (GnRH) and gastrointestinal function. The aim of the study was to prospectively investigate women subjected to in vitro fertilization (IVF) using the GnRH analog buserelin, taking into account gastrointestinal symptoms and antibody development against buserelin, GnRH, luteinizing hormone (LH), and their receptors. METHODS: Gastrointestinal symptoms were registered by the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) before and after IVF treatment, and five years later. Health-related quality of life was evaluated by the 36-item Short-Form questionnaire (SF-36). ELISA was used for antibody analyses before and after treatment. Data were compared with women from the general population. RESULTS: In total, 124 patients were investigated before and after IVF, and 62 were re-evaluated after five years. Buserelin treatment led to significant impairment of constipation (p = 0.004), nausea and vomiting (p = 0.035), psychological well-being (p = 0.000), and the intestinal symptoms' influence on daily life (p = 0.027). At 5-year follow-up, abdominal pain was worsened (p = 0.041), but psychological well-being was improved (p = 0.036), compared to prior treatment, and 15% had an observable deterioration in gastrointestinal symptoms. None developed severe dysmotility. Patients had higher prevalence of IgG antibodies against LH (p = 0.001) and its receptor (p = 0.016), and IgM antibodies against the GnRH receptor (p = 0.001) prior treatment compared with controls, but no antibody development was observed after IVF. CONCLUSION: Patients experience gastrointestinal symptoms during buserelin treatment, and abdominal pain is still increased after five years, but buserelin does not increase antibody formation against GnRH, LH or their receptors.
DOI http://dx.doi.org/10.1186/1471-2393-13-201 (link to publisher's fulltext.)
Link http://www.biomedcentral.com/1471-2393/13/201 (external link to publication)
Publisher BioMed Central
Host/Issue BMC Pregnancy and Childbirth;
Volume 13
ISSN 1471-2393
Pages 201
Language eng (iso)
Subject(s) Abdominal pain
Gastrointestinal symptoms
Gonadotropin-releasing hormone
In vitro fertilization
Luteinizing hormone
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/16855 (link to this page)

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