Effects of experimental tooth clenching on pain and intramuscular release of 5-HT and glutamate in patients with myofascial TMD

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Effects of experimental tooth clenching on pain and intramuscular release of 5-HT and glutamate in patients with myofascial TMD

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Publication Article, peer reviewed scientific
Title Effects of experimental tooth clenching on pain and intramuscular release of 5-HT and glutamate in patients with myofascial TMD
Author(s) Dawson, Andreas ; Ghafouri, Bijar ; Gerdle, Björn ; List, Thomas ; Svensson, Peter ; Ernberg, Malin
Date 2014
English abstract
OBJECTIVES:: It has been suggested that tooth clenching may be associated with local metabolic changes, and is a risk factor for myofascial temporomandibular disorders (M-TMD). This study investigated the effects of experimental tooth clenching on the levels of 5-HT, glutamate, pyruvate, and lactate, as well as on blood flow and pain intensity, in the masseter muscles of M-TMD patients. METHODS:: Fifteen patients with M-TMD and 15 healthy controls participated. Intramuscular microdialysis was done to collect 5-HT, glutamate, pyruvate, and lactate and to assess blood flow. Two hours after the insertion of a microdialysis catheter, participants performed a 20-min repetitive tooth clenching task (50% of maximal voluntary contraction). Pain intensity was measured throughout. RESULTS:: A significant effect of group (P<0.01), but not of time, was observed on 5-HT levels, and blood flow. No significant effects of time or group occurred on glutamate, pyruvate, or lactate levels. Time and group had significant main effects on pain intensity (P<0.05, and P<0.001). No significant correlations were identified between: (i) 5-HT, glutamate, and pain intensity or between (ii) pyruvate, lactate, and blood flow. DISCUSSION:: This experimental tooth clenching model increased jaw muscle pain levels in M-TMD patients and evoked low levels of jaw muscle pain in healthy controls. M-TMD patients had significantly higher levels of 5-HT than healthy controls and significantly lower blood flow. These two factors may facilitate the release of other algesic substances that may cause pain.
DOI http://dx.doi.org/10.1097/AJP.0000000000000154 (link to publisher's fulltext)
Publisher Raven Press
Host/Issue The Clinical journal of pain;8
Volume 31
ISSN 0749-8047
Pages 740-749
Language eng (iso)
Subject(s) Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/17981 (link to this page)

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