Diabetes and oral implant failure : a systematic review

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Diabetes and oral implant failure : a systematic review

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Publication Article, review peer-reviewed scientific
Title Diabetes and oral implant failure : a systematic review
Author(s) Chrcanovic, Bruno ; Albrektsson, Tomas ; Wennerberg, Ann
Date 2014
English abstract
The aim of this systematic review and meta-analysis was to investigate whether there are any effects of diabetes mellitus on implant failure rates, postoperative infections, and marginal bone loss. An electronic search without time or language restrictions was undertaken in March 2014. The present review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligibility criteria included clinical human studies. The search strategy resulted in 14 publications. The I (2) statistic was used to express the percentage of total variation across studies due to heterogeneity. The inverse variance method was used for the random effects model when heterogeneity was detected or for the fixed effects model when heterogeneity was not detected. The estimates of an intervention for dichotomous outcomes were expressed in risk ratio and in mean difference in millimeters for continuous outcomes, both with a 95% confidence interval. There was a statistically significant difference (p = .001; mean difference = 0.20, 95% confidence interval = 0.08, 0.31) between diabetic and non-diabetic patients concerning marginal bone loss, favoring non-diabetic patients. A meta-analysis was not possible for postoperative infections. The difference between the patients (diabetic vs. non-diabetic) did not significantly affect implant failure rates (p = .65), with a risk ratio of 1.07 (95% confidence interval = 0.80, 1.44). Studies are lacking that include both patient types, with larger sample sizes, and that report the outcome data separately for each group. The results of the present meta-analysis should be interpreted with caution because of the presence of uncontrolled confounding factors in the included studies.
DOI http://dx.doi.org/10.1177/0022034514538820 (link to publisher's fulltext)
Publisher SAGE
Host/Issue Journal of Dental Research;9
Volume 93
ISSN 0022-0345
Pages 859-867
Language eng (iso)
Subject(s) Diabetes mellitus
Blood glucose
Dental implants
Infection
Periodontal bone loss
Meta-analysis
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/18021 (link to this page)

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