The influence of 1α.25-dihydroxyvitamin d3 coating on implant osseointegration in the rabbit tibia

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The influence of 1α.25-dihydroxyvitamin d3 coating on implant osseointegration in the rabbit tibia

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Publication Article, peer reviewed scientific
Title The influence of 1α.25-dihydroxyvitamin d3 coating on implant osseointegration in the rabbit tibia
Author(s) Naito, Yoshihito ; Jimbo, Ryo ; Vandeweghe, Stefan ; Chrcanovic, Bruno ; Tovar, Nick ; Bryington, Matthew ; Ichikawa, Tetsuo ; Coelho, Paulo ; Wennerberg, Ann
Date 2014
English abstract
OBJECTIVES: This study aims to evaluate bone response to an implant surface modified by 1α,25-dihydroxyvitamin D3 [1.25-(OH)2D3] in vivo and the potential link between 1.25-(OH) 2D3 surface concentration and bone response. MATERIAL AND METHODS: Twenty-eight implants were divided into 4 groups (1 uncoated control, 3 groups coated with 1.25-(OH)2D3 in concentrations of 10(-8), 10(-7) and 10(-6) M respectively), placed in the rabbit tibia for 6 weeks. Topographical analyses were carried out on coated and uncoated discs using interferometer and atomic-force-microscope (AFM). Twenty-eight implants were histologically observed (bone-to-implant-contact [BIC] and new-bone-area [NBA]). RESULTS: The results showed that the 1.25-(OH)2D3 coated implants presented a tendency to osseointegrate better than the non-coated surfaces, the differences were not significant (P > 0.05). CONCLUSIONS: The effect of 1.25-(OH)2D3 coating to implants suggested possible dose dependent effects, however no statistical differences could be found. It is thought that the base substrate topography (turned) could not sustain sufficient amount of 1.25-(OH)2D3 enough to present significant biologic responses. Thus, development a base substrate that can sustain 1.25-(OH)2D3 for a long period is necessary in future studies.
DOI http://dx.doi.org/10.5037/jomr.2014.5303 (link to publisher's fulltext)
Publisher STILUS OPTIMUS
Host/Issue Journal of Oral and Maxillofacial Research;3
Volume 5
ISSN 2029-283X
Pages e3
Language eng (iso)
Subject(s) Dental implants
Vitamin D
Drug dose response relationship
Histological techniques
Bone formation
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/18141 (link to this page)

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