Amperometric in vitro monitoring of penetration through skin membrane

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Amperometric in vitro monitoring of penetration through skin membrane

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Publication Article, peer reviewed scientific
Title Amperometric in vitro monitoring of penetration through skin membrane
Author(s) Gari, Hala ; Rembiesa, Jadwiga ; Masilionis, Ignas ; Vreda, Naida ; Svensson, Birgitta ; Sund, Torbjörn ; Hansson, Henri ; Morén, Anna Karin ; Sjöö, Malin ; Wahlgren, Marie ; Engblom, Johan ; Ruzgas, Tautgirdas
Date 2015
English abstract
The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From realtime measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.
DOI http://dx.doi.org/10.1002/elan.201400426 (link to publisher's fulltext)
Publisher Wiley
Host/Issue Electroanalysis;1
Volume 27
ISSN 1521-4109
Pages 111-117
Language eng (iso)
Subject(s) Penetration
Transdermal delivery
Amperometry
Quercetin
Hydrogen peroxide
Ascorbic acid
Skin membrane
Medicine
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/18354 (link to this page)

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