Chromatographycally efficient microspherical composites of molecularly imprinted xerogels deposited inside mesoporous silica

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Chromatographycally efficient microspherical composites of molecularly imprinted xerogels deposited inside mesoporous silica

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Publication Article, peer reviewed scientific
Title Chromatographycally efficient microspherical composites of molecularly imprinted xerogels deposited inside mesoporous silica
Author(s) Kadhirvel, Porkodi ; Azenha, Manuel ; Silva, Fernando ; Sellergren, Börje
Date 2014
English abstract
A different approach to the preparation of microspheric particles of molecularly imprinted xerogels (MIX) is presented here. The technique consisted of filling up the pores of spherical, mesoporous, bare silica particles with a pregelification mixture by applying pressure. Upon gelification and drying, thin layers of MIX were deposited on the mesopores. Spherical composites of S-naproxen (S-NAP) imprints were produced by following this simple strategy. The performance of the imprints was quite satisfactory in terms of recognition ability (ascertained by selectivity against ibuprofen, α=4.9, and an imprinting factor of 13) whereas an outstanding improvement on dynamic features (expressed as column efficiency), as compared to the corresponding bulk format MIX (9 vs. 1.2 theoretical plates/cm), was reached
DOI http://dx.doi.org/10.1016/j.chroma.2014.06.013 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Journal of chromatography. A.;
Volume 1355
ISSN 0021-9673
Pages 158-163
Language eng (iso)
Subject(s) Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/18386 (link to this page)

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