Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide

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Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide

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Publication Article, peer reviewed scientific
Title Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide
Author(s) Kadhirvel, Porkodi ; Azenha, Manuel ; Schillinger, Eric ; Halhalli, Mahadeo ; Silva, Antonio ; Sellergren, Börje
Date 2014
English abstract
Straightforward crushing and sieving bulk polymeric R-aminoglutethimide-imprinted materials were prepared by classical free radical polymerization, whereas nano thin walled grafted imprinted materials were prepared using RAFT mediated control polymerization technique. A stoichiometric non-covalent approach based on a triply hydrogen bonding functional monomer-template 1:1 complex (K=599mol(-1)L(-1)) led to chiral selectors far outperforming previously used selectors for resolving this racemate. The recognitive materials produced here (enantioselectivity factors, α∼10) also have no match within the previously reported enantioselective imprinted polymers (α 1.2-4.5). We here demonstrate a potentially generic solution to produce good quality grafted MIPs for templates interacting by hydrogen bonding alone, relying on solvent polarity tuning, significantly extending the range of templates compatible with this format.
DOI http://dx.doi.org/10.1016/j.chroma.2014.06.076 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Journal of chromatography. A.;
Volume 1358
ISSN 0021-9673
Pages 93-101
Language eng (iso)
Subject(s) Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/18390 (link to this page)

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