Lipidomic “Deep Profiling” : An Enhanced Workflow to Reveal New Molecular Species of Signaling Lipids

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Lipidomic “Deep Profiling” : An Enhanced Workflow to Reveal New Molecular Species of Signaling Lipids

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Publication Article, peer reviewed scientific
Title Lipidomic “Deep Profiling” : An Enhanced Workflow to Reveal New Molecular Species of Signaling Lipids
Author(s) Narayanaswamy, Pradeep ; Shinde, Sudhirkumar ; Sulc, Robert ; Kraut, Rachel ; Staples, Gregory ; Thiam, Chung Hwee ; Grimm, Rudolf ; Sellergren, Börje ; Torta, Federico ; Wenk, Markus R.
Date 2014
English abstract
Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of lipid classes. We introduce a strategy to capture phospho-monoester lipids and improve the detection of long-chain base phosphates (LCB-Ps, e.g., sphingosine-1-phosphate). Ten novel LCB-Ps (d18:2, t20:1, odd carbon forms) were discovered and characterized in tissues from human and mouse, as well in D. melanogaster and S. cerevisiae. These findings have immediate relevance for our understanding of sphingosine-1-phosphate biosynthesis, signaling, and degradation.
DOI http://dx.doi.org/10.1021/ac4039652 (link to publisher's fulltext)
Publisher American Chemical Society
Host/Issue Analytical Chemistry;6
Volume 86
ISSN 0003-2700
Pages 3043-3047
Language eng (iso)
Subject(s) Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/18392 (link to this page)

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