Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries

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Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries

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Publication Article, peer reviewed scientific
Title Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries
Author(s) Kecili, Rüstem ; Billing, Johan ; Nivhede, David ; Sellergren, Börje ; Rees, Anthony ; Yilmaz, Ecevit
Date 2014
English abstract
This study describes the identification and evaluation of molecularly imprinted polymers (MIPs) for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals. Screening experiments were performed using existing MIP resin libraries to identify resins selective towards those impurities in the presence of model pharmaceutical compounds. A hit resin with a considerable imprinting effect was found in the screening and upon further investigation, the resin was found to show a broad selectivity towards five different aminopyridines in the presence of the two model active pharmaceutical ingredients (APIs) piroxicam and tenoxicam.
DOI http://dx.doi.org/10.1016/j.chroma.2014.02.073 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Journal of Chromatography A;
Volume 1339
ISSN 0021-9673
Pages 65-72
Language eng (iso)
Subject(s) Active pharmaceutical ingredients
Aminopyridines
Genotoxic impurities
Molecularly imprinted polymers
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/18394 (link to this page)

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