Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen : Comparison of acrylic and sol–gel approaches

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Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen : Comparison of acrylic and sol–gel approaches

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Publication Article, peer reviewed scientific
Title Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen : Comparison of acrylic and sol–gel approaches
Author(s) Kadhirvel, Porkodi ; Azenha, Manuel ; Shinde, Sudhirkumar ; Schillinger, Eric ; Gomes, Paula ; Sellergren, Börje ; Silva, Fernando
Date 2013
English abstract
Imidazolium-based monomers were, for the first time, employed in a comprehensive investigation of the molecular imprinting process of naproxen in both acrylic and sol-gel tridimensional networks. To this end, molecularly imprinted polymer (MIP) and xerogel (MIX) were both optimized for performance, by testing different porogen, template speciation and component ratios. The developed imprints were characterized for their pore properties (nitrogen adsorption analysis), site heterogeneity, binding properties and other performance parameters such as the imprinting factor, selectivity (HPLC column tests), column efficiency and mass transfer kinetics (frontal analysis study). MIP exhibited mesoporosity (Dp 29nm), whereas MIX did not, which was reflected in both the lower number of accessible imprinted sites (4.9μmol/g versus 3.7μmol/g) and the slower binding/dissociation in MIX. The naproxen/ibuprofen selectivity ratio was estimated as 6.2 for the MIX and 2.5 for the MIP. Given the high importance of capacity and fast mass transfer in typical applications of imprinted materials, and the satisfactory selectivity of MIP, it can be concluded that the acrylic approach was globally the most advantageous. Still, the remarkably high selectivity of MIX and its reasonable capacity demonstrate that future work devoted to further optimization of both formats is worthwhile.
DOI http://dx.doi.org/10.1016/j.chroma.2013.09.015 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Journal of Chromatography A;
Volume 1314
ISSN 0021-9673
Pages 115-123
Language eng (iso)
Subject(s) Cationic monomer
Frontal analysis
Methacrylic polymer
Molecular imprinting
Naproxen
Sol-gel
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/18417 (link to this page)

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