Sphingoid Bases Inhibit Acid-Induced Demineralization of Hydroxyapatite

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Sphingoid Bases Inhibit Acid-Induced Demineralization of Hydroxyapatite


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Publication Article, peer reviewed scientific
Title Sphingoid Bases Inhibit Acid-Induced Demineralization of Hydroxyapatite
Author Valentijn-Benz, Marianne ; van 't Hof, Wim ; Bikker, Floris J ; Nazmi, Kamran ; Brand, Henk S ; Sotres, Javier ; Lindh, Liselott ; Arnebrant, Thomas ; Veerman, Enno C I
Date 2015
English abstract
Calcium hydroxyapatite (HAp), the main constituent of dental enamel, is inherently susceptible to the etching and dissolving action of acids, resulting in tooth decay such as dental caries and dental erosion. Since the prevalence of erosive wear is gradually increasing, there is urgent need for agents that protect the enamel against erosive attacks. In the present study we studied in vitro the anti-erosive effects of a number of sphingolipids and sphingoid bases, which form the backbone of sphingolipids. Pretreatment of HAp discs with sphingosine, phytosphingosine (PHS), PHS phosphate and sphinganine significantly protected these against acid-induced demineralization by 80 ± 17%, 78 ± 17%, 78 ± 7% and 81 ± 8%, respectively (p < 0.001). On the other hand, sphingomyelin, acetyl PHS, octanoyl PHS and stearoyl PHS had no anti-erosive effects. Atomic force measurement revealed that HAp discs treated with PHS were almost completely and homogeneously covered by patches of PHS. This suggests that PHS and other sphingoid bases form layers on the surface of HAp, which act as diffusion barriers against H+ ions. In principle, these anti-erosive properties make PHS and related sphingosines promising and attractive candidates as ingredients in oral care products.
DOI https://doi.org/10.1159/000362096 (link to publisher's fulltext.)
Publisher Karger
Host/Issue Caries Research;1
Volume 49
ISSN 0008-6568
Pages 9-17
Language eng (iso)
Subject Erosion
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/18610 Permalink to this page

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