Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches

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Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches

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Publication Article, peer reviewed scientific
Title Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches
Author(s) Miftakhova, Regina ; Hedblom, Andreas ; Batkiewicz, Leah ; Anagnosaki, Lola ; Zhang, Yuan ; Sjölander, Anita ; Gjörloff Wingren, Anette ; Wolgemut, Debra J ; Persson, Jenny L
Date 2015
English abstract
It remains poorly understood how the haematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired proliferation and homing of HSPC in the BM of cyclin A1-null mice are attributed to the increased density of microvessels in the endosteal and central BM niche zones, which is associated with the increased VEGFR1 expression. Thus, modulation of cyclin A1 and VEGFR1 in HSPC and their niches may provide new insights into therapeutic approaches.
DOI http://dx.doi.org/10.1080/15384101.2015.1026513 (link to publisher's fulltext)
Publisher Taylor & Francis
Host/Issue Cell Cycle;12
Volume 14
ISSN 1538-4101
Pages 1948-1960
Language eng (iso)
Subject(s) bone marrow transplantation
cyclin A
progenitor cell
homing
migration
VEGFR1
hematopoetic stem cell
Medicine
Research Subject Categories::MEDICINE
Handle http://hdl.handle.net/2043/19504 (link to this page)

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