Deficient cytokine control modulates temporomandibular joint pain in rheumatoid arthritis

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Deficient cytokine control modulates temporomandibular joint pain in rheumatoid arthritis

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Publication Article, peer reviewed scientific
Title Deficient cytokine control modulates temporomandibular joint pain in rheumatoid arthritis
Author(s) Ahmed, Naveen ; Catrina, Anca I ; Alyamani, Ahmed O ; Mustafa, Hamid ; Alstergren, Per
Date 2015
English abstract
The aim was to investigate how endogenous cytokine control of tumor necrosis factor (TNF) influences temporomandibular joint (TMJ) pain in relation to the role of anti-citrullinated peptide antibodies (ACPA) in patients with rheumatoid arthritis (RA). Twenty-six consecutive patients with TMJ RA were included. Temporomandibular joint pain intensity was assessed at rest, on maximum mouth opening, on chewing, and on palpation. Mandibular movement capacity and degree of anterior open bite (a clinical sign of structural destruction of TMJ tissues) were also assessed. Systemic inflammatory activity was assessed using the Disease Activity Score in 28 joints (DAS28) for rheumatoid arthritis. Samples of TMJ synovial fluid and blood were obtained and analyzed for TNF, its soluble receptor, soluble TNF receptor II (TNFsRII), and ACPA. A high concentration of TNF in relation to the concentration of TNFsRII in TMJ synovial fluid was associated with TMJ pain on posterior palpation on maximum mouth opening. The ACPA concentration correlated significantly to the TNF concentration, but not to the TNFsRII concentration, indicating that increased inflammatory activity is mainly caused by an insufficient increase in anti-inflammatory mediators. This study indicates that TMJ pain on palpation in patients with RA is related to a deficiency in local cytokine control that contributes to increased inflammatory activity, including sensitization to mechanical stimuli over the TMJ.
DOI http://dx.doi.org/10.1111/eos.12193 (link to publisher's fulltext)
Publisher Wiley
Host/Issue European journal of oral sciences;4
Volume 123
ISSN 0909-8836
Pages 235-241
Language eng (iso)
Subject(s) pain
rheumatoid arthritis
synovial fluid
temporomandibular joint
tumor necrosis factor
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/19657 (link to this page)

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