Tumor necrosis factor mediates temporomandibular joint bone tissue resorption in rheumatoid arthritis

DSpace Repository

Tumor necrosis factor mediates temporomandibular joint bone tissue resorption in rheumatoid arthritis

Show full item record

Files for download

Find Full text There are no files associated with this item..

Facebook

Simple item record

Publication Article, peer reviewed scientific
Title Tumor necrosis factor mediates temporomandibular joint bone tissue resorption in rheumatoid arthritis
Author(s) Ahmed, Naveen ; Petersson, Arne ; Catrina, Anca ; Mustafa, Hamid ; Alstergren, Per
Date 2015
English abstract
OBJECTIVE: To investigate if TNF, IL-1 or their endogenous controls, in relation to ACPA, are associated with radiological signs of ongoing temporomandibular joint (TMJ) bone tissue resorption and disc displacement in RA patients. METHODS: Twenty-two consecutive outpatients with TMJ of RA were included. Systemic inflammatory activity was assessed by DAS28. The number of painful regions in the body and ESR, CRP, RF and ACPA were analyzed. TMJ synovial fluid and blood samples were obtained and analyzed for TNF, TNFsRII, IL-1ra, IL-1sRII and ACPA. The ratios between the mediators and their endogenous control receptors were used in the statistical analysis. Magnetic resonance imaging was performed in closed- and open-mouth positions and evaluated regarding disc position and presence of condylar and temporal erosions of the TMJ. RESULTS: A high TNF level in relation to TNFsRII in TMJ synovial fluid correlated to the degree of TMJ condylar erosion. A high IL-1ra level in relation to TNF in TMJ synovial fluid was also correlated to the degree of TMJ condylar erosion. The total degree of TMJ condylar erosion was correlated with the number of painful regions. CONCLUSION: This study indicates that TNF in TMJ synovial fluid mediates TMJ cartilage and bone tissue resorption in RA. The study also suggests that the degree of endogenous cytokine control is of importance for development of bone tissue destruction.
DOI http://dx.doi.org/10.3109/00016357.2014.994561 (link to publisher's fulltext)
Publisher Taylor & Francis
Host/Issue Acta Odontologica Scandinavica;3
Volume 73
ISSN 0001-6357
Pages 232-240
Language eng (iso)
Subject(s) MRI
TMJ
cytokines
disc displacement
erosion
rheumatoid arthritis
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/19660 (link to this page)

This item appears in the following Collection(s)

Show full item record

Search


Browse

My Account

Statistics