The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces : a study in humans

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The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces : a study in humans

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Publication Article, peer reviewed scientific
Title The soft tissue immunologic response to hydroxyapatite-coated transmucosal implant surfaces : a study in humans
Author(s) De Wilde, Elisabeth A. W. J. ; Jimbo, Ryo ; Wennerberg, Ann ; Naito, Yoshihito ; Coucke, Paul ; Bryington, Matthew S. ; Vandeweghe, Stefan ; De Bruyn, Hugo
Date 2015
English abstract
ObjectiveTo evaluate the soft tissue response in humans immunologically and histologically after placement of mini-implants coated with or without nano-size hydroxyapatite coatings. Material and MethodsCommercially pure (cp) titanium mini-implants (n=13) or nano-hydroxyapatite-coated ones (n=12) were randomly placed into partially edentulous jaws. Crevicular fluid was sampled 1week after placement and subjected to quantitative polymerase chain reaction analysis to explore the inflammatory markers. After 8weeks, implants and surrounding soft and hard tissue were trephined, and undecalcified ground sections were prepared. Inflammatory cell accumulation within a defined region of interest in the soft tissue was quantified histomorphometrically. ResultsNo statistically significant differences in immunological response to the different implant surfaces were found for IL-6 (p=.438), TGF-2 (p=.467), MMP-8 (p=.758), CCL-3 (p=.758), IL-8 (p=.771), and IL-1 (0.771). Histomorphometric evaluation presented no statistically significant difference between the two mini-implant surfaces with regards to number of inflammatory cells (p=.669). ConclusionNano-hydroxyapatite-coated surfaces in the transmucosal region yielded similar inflammatory response and is suggested to be as biocompatible as commercially pure titanium surfaces.
DOI http://dx.doi.org/10.1111/cid.12128 (link to publisher's fulltext)
Publisher Wiley
Host/Issue Clinical Implant Dentistry and Related Research;S1
Volume 17
ISSN 1523-0899
Pages E65-E74
Language eng (iso)
Subject(s) dental implant
gene expression
human
hydroxyapatite
nanotopography
osseointegration
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/19778 (link to this page)

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