On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture

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On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture

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Publication Article, peer reviewed scientific
Title On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
Author Lind, Tania K. ; Polcyn, Piotr ; Zielinska, Paulina ; Cardenas, Marite ; Urbanczyk-Lipkowska, Zofia
Research Centre Biofilms - Research Center for Biointerfaces
Date 2015
English abstract
Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity.
DOI https://doi.org/10.3390/molecules20010738 (link to publisher's fulltext.)
Publisher MDPI
Host/Issue Molecules;1
Volume 20
ISSN 1420-3049
Pages 738-753
Language eng (iso)
Subject dendrimers
peptide
antimicrobial
lipids
Sciences
Research Subject Categories::INTERDISCIPLINARY RESEARCH AREAS
Handle http://hdl.handle.net/2043/19804 Permalink to this page
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