Non-lamellar lipid liquid crystalline structures at interfaces

DSpace Repository

Non-lamellar lipid liquid crystalline structures at interfaces

Show full item record

Files for download

Find Full text There are no files associated with this item..

Facebook

Simple item record

Publication Article, review peer-reviewed scientific
Title Non-lamellar lipid liquid crystalline structures at interfaces
Author(s) Chang, Debby P. ; Barauskas, Justas ; Dabkowska, Aleksandra P. ; Wadsäter, Maria ; Tiberg, Fredrik ; Nylander, Tommy
Date 2015
English abstract
The self-assembly of lipids leads to the formation of a rich variety of nano-structures, not only restricted to lipid bilayers, but also encompassing non-lamellar liquid crystalline structures, such as cubic, hexagonal, and sponge phases. These non-lamellar phases have been increasingly recognized as important for living systems, both in terms of providing compartmentalization and as regulators of biological activity. Consequently, they are of great interest for their potential as delivery systems in pharmaceutical, food and cosmetic applications. The compartmentalizing nature of these phases features mono- or bicontinuous networks of both hydrophilic and hydrophobic domains. To utilize these non-lamellar liquid crystalline structures in biomedical devices for analyses and drug delivery, it is crucial to understand how they interact with and respond to different types of interfaces. Such non-lamellar interfacial layers can be used to entrap functional biomolecules that respond to lipid curvature as well as the confinement. It is also important to understand the structural changes of deposited lipid in relation to the corresponding bulk dispersions. They can be controlled by changing the lipid composition or by introducing components that can alter the curvature or by deposition on nano-structured surface, e.g. vertical nano-wire arrays. Progress in the area of liquid crystalline lipid based nanoparticles opens up new possibilities for the preparation of well-defined surface films with well-defined nano-structures. This review will focus on recent progress in the formation of non-lamellar dispersions and their interfacial properties at the solid/liquid and biologically relevant interfaces.
DOI http://dx.doi.org/10.1016/j.cis.2014.11.003 (link to publisher's fulltext)
Publisher Elsevier
Host/Issue Advances in Colloid and Interface Science;
Volume 222
ISSN 0001-8686
Pages 135-147
Language eng (iso)
Subject(s) X-RAY-DIFFRACTION
POLYMORPHIC PHASE-BEHAVIOR
SELF-ASSEMBLY STRUCTURES
DRUG-DELIVERY VEHICLES
CUBIC-PHASE
MODEL MEMBRANES
HYDROPHOBIC SURFACES
MEDICAL APPLICATIONS
Sciences
Research Subject Categories::NATURAL SCIENCES
Handle http://hdl.handle.net/2043/19838 (link to this page)

This item appears in the following Collection(s)

Show full item record

Search


Browse

My Account

Statistics