Bone Regenerative Potential of Modified Biphasic Graft Materials

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Bone Regenerative Potential of Modified Biphasic Graft Materials

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Publication Article, peer reviewed scientific
Title Bone Regenerative Potential of Modified Biphasic Graft Materials
Author(s) Khan, Rehan ; Witek, Lukasz ; Breit, Matthew ; Colon, Dinely ; Tovar, Nick ; Janal, Malvin N. ; Jimbo, Ryo ; Coelho, Paulo G.
Date 2015
English abstract
Purpose: To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials. Materials and Methods: The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss T, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis. Results: Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks. Conclusion: Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial.
DOI http://dx.doi.org/10.1097/ID.0000000000000220 (link to publisher's fulltext)
Publisher Lippincott
Host/Issue Implant Dentistry;2
Volume 24
ISSN 1056-6163
Pages 149-154
Language eng (iso)
Subject(s) bone grafts
hydroxyapatite
tricalcium phosphate
poly-lactic-co-glycolic acid
histomorphometry
Medicine
Research Subject Categories::ODONTOLOGY
Handle http://hdl.handle.net/2043/20046 (link to this page)

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